Publications: Peer-reviewed journal articles (by staff)

Pinnatoxin H: a new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate

1 January, 2014
CITATION

Selwood AI, Wilkins AL, Munday R, Gu H, Smith KF, Rhodes L, Rise F 2014. Pinnatoxin H: a new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate. Tetrahedron Letters 10/2014; 55(40):5508–5510.

ABSTRACT

Pinnatoxin H was isolated from a culture of the dinoflagellate Vulcanodinium rugosum isolated from the South China Sea. The structure of pinnatoxin H was elucidated by LC–MS/MS and NMR spectroscopy. It was found to have the same macrocyclic structure and substituents as pinnatoxins D, E and F, but the side chain on the cyclohexenyl ring was an ethenyl group, as found in pinnatoxin G and portimine. The observation that this strain of V. rugosum produced only pinnatoxin H and portimine is consistent with previous findings that the profile of pinnatoxins can vary significantly among strains. The acute toxicity of pinnatoxin H to mice was 67 μg/kg (intraperitoneal) and 163 μg/kg (gavage).