Publications: Peer-reviewed journal articles (by staff)
44-Methylgambierone, a new gambierone analogue isolated from Gambierdiscus australes
Murray JS, Selwood A, Harwood DT, van Ginkel R, Puddick J, Rhodes L, Rise F, Wilkins A. 2019. 44-Methylgambierone, a new gambierone analogue isolated from Gambierdiscus australes. Tetrahedron Letters.
DOI link here
A new analogue of gambierone, 44-methylgambierone, was isolated from the benthic dinoflagellate Gambierdiscus australes collected from Raoul Island (Rangitahua/Kermadec Islands). This molecule has been previously reported as maitotoxin-3. The structure of 44-methylgambierone was elucidated using 1D- and 2D-nuclear magnetic resonance spectroscopy and mass spectrometry techniques. The nine-ring polyether backbone (A–I) and functional groups (carbonyl, terminal diol, 1,3-diene and monosulphate) are the same for both compounds with the addition of an olefinic methyl group being the only modification in 44-methylgambierone.